Monday, May 17, 2010

Cell Phones and Cancer: a Study's Muddled Findings

It has become one of the most controversial questions in cancer medicine: can using a cell phone cause brain tumors? The federal government and the mobile industry have maintained there is no conclusive data to support a link between cell-phone radiation and cancer, but a growing band of scientists are skeptical, suggesting that the evidence that does exist is enough to raise a warning for consumers — before mass harm is done.
What scientists and regulators need is truly conclusive scientific evidence. Enter Interphone, a $24 million long-term study that matched rates of brain cancer with cell-phone use among more than 12,000 participants (including 7,400 who developed tumors) in 13 countries. The long-awaited report — whose findings were finally released Monday after years of delay — is by the far the most comprehensive look at the issue to date, and was designed to provide the final word on the debate. (See a photographic history of the cell phone.)
Unfortunately, however, the results turned out to be anything but clear. The study, which will be published this week in the International Journal of Epidemiology, found that, overall, there was no clear connection between cell-phone use and brain cancer. "An increased risk of brain cancer is not established from the data from Interphone," said Dr. Christopher Wild, the director of the International Agency for Research on Cancer, which helped coordinate the study.
But upon closer inspection the results were checkered: the 10% of people who used their phones most often and for the longest period of time — 30 minutes a day or more on average for at least 10 years — had a substantially higher risk of developing some forms of brain cancer than those who didn't use a mobile at all. Meanwhile, people who used their cell phones infrequently had a lower risk of developing some brain tumors than those who exclusively used corded telephones — as if mobile phones in small doses might offer some protection from brain cancer. (See TIME's special: America's Health Checkup.)
The mobile-phone industry was quick to trumpet Interphone's most basic results. The overall finding "is in accordance with the large body of existing research and many expert reviews that consistently conclude there is no established health risk from radio signals that comply with international safety recommendations," said Jack Rowley, director of research and sustainability for the GSM Association, which represents hundreds of mobile phone makers and operators, in a statement.
But consumer advocates, who have in the past raised concerns about the safety of mobile phones, countered that the study did find cancer risks for heavy users. More troubling than that, they say, are the apparent methodological problems in the study itself. The fact that all but the heaviest users of cell phones actually had a smaller risk of developing a brain tumor than those who never used mobile phones at all almost certainly demonstrates a flaw in the study design. If there had been a true zero risk from mobile-phone use, a well-designed study would have shown no difference in brain-cancer rates between cell-phone users and nonusers. "Bias stands as the most likely explanation of the observed results," wrote epidemiologists Rodolfo Saracci and Jonathan Samet in an editorial accompanying the study. (Read a TIME piece on how cancer threats are present in many not-so-hidden places.)
Further, if cell-phone use posed no increased risk of brain cancer, it doesn't logically follow that heavy users would have a 40% higher incidence of glioma (a certain form of brain tumor) than the control group, as the study found. It's worth keeping in mind also that "heavy" users as defined by the Interphone study — 30 minutes of cell-phone use a day — are not what we might consider heavy today: average use now is 21 minutes per day. (Interphone's heavy user would require 900 cell-phone minutes a month — the mid-level usage category for AT&T wireless plans.)
Importantly, Interphone — the results of which are now five-and-a-half years old — does not take into account the impact of mobile phone use in children, whose skulls are thinner than adults, and who may be more sensitive to cell phone radiation. Nor does it include any data on U.S. users.
Of course, the study doesn't make a conclusive argument that cell phones cause brain cancer either. Indeed, there's no scientific agreement on how cell-phone radiation might even biologically cause a tumor. (Mobile-phone radiation is non-ionizing, unlike carcinogenic X-rays.) Instead of offering clear answers, Interphone just raises more questions. "Further investigation of mobile-phone use and brain-cancer risk is merited," said Dr. Christopher Wild, the director of the International Agency for Research on Cancer, which helped coordinate the study. That's one thing the mobile-phone industry and its opponents can agree on.never give up
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It is autumn. The sky is clem and cloudless. The summer heat is gone. The autumn wind brings us cool. At once the version comes to my mind, "Autumn is rich with fruit and grain. " Actually I see pomegranates red and round on the stall in the market and the pcars big, yellow and juicy. My mouth waters for them. The grains have been harvested, the rice, wheat and corn. The laurel trees give off fragrance. The perfume makes its way stralght into my nose. The brlght red canna are standing behind rows of tall plane trees. I am waiting for their leaves to turn yellow.Then l can trample on the fallen leaves on both sides of the ground. At times the autumn rain keeps falling silandy on the trees and flowers and the ground. It washes everything clean. When the sun comes out, the droplets shine bright on the yellow leaves. What a beautiful painting! Autumn is the season for harvest no pains, no gains. I must study hard so that I can have a big harvest in all my subjects.
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